Cinnamonitrilecistrans - China

Preparation

The aqueous solution of hydroxylamine hydrochloride and sodium carbonate was prepared by mixing anhydrous sodium carbonate, hydroxylamine hydrochloride and water.

Then the aqueous solution of hydroxylamine hydrochloride and sodium carbonate was added to the solution of cinnamaldehyde and ethanol or methanol, stirred and set it well.

Then the reaction mixture was poured into the ice water until the white precipitate was precipitated, the white precipitate was filtered out and washed with water, then the cinnamaldehyde oxime was obtained after drying.

Acetic anhydride of 2o 2.5 times (mole ratio) was dripped into cinnamaldehyde oxime, stirred for dehydration and cooled, then vacuum distillation was used to recover acetic anhydride and acetic acid produced by the reaction, and then vacuum distillation was carried out.

Cinnamonitrile was obtained by collecting stable fractions at 130C / 2064pa or 151.0 ℃ / 5330pa.

The method has the advantages of simple operation, low raw material, no pollution and high yield.

Rapid Synthesis of Trans-cinnamonitrile

Acetonitrile, potassium hydroxide and benzaldehyde were used as raw materials in acetonitrile solvent, stirred and refluxed (10 min), hydrolyzed by crushed ice, heated under normal pressure and distilled under reduced pressure to rapidly synthesize trans-cinnamonitrile.

The yield was 48%-54%.

The application of organic carbon anion nucleophilic addition reaction mechanism in organic synthesis was studied.

The structure of the product was characterized by UV-Vis, FTIR and HNMR, and it was confirmed that the product was the target product.

The results showed that trans cinnamonitrile could be synthesized rapidly under mild conditions using potassium hydroxide benzaldehyde and acetonitrile as raw materials according to the mechanism of nucleophilic addition of organic carbon anion.

Company Contact:

• Posted By: Wuhan LANDMARK Industrial Co., Ltd.

• Phone: 02783916065

• Address: Jiang'an District of Wuhan, Wuhan , China

• Email:

• Website: https://www.landmarkind.com

• Business Description: The company's main products are: cinnamic acid, cinnamaldehyde, cinnamon alcohol, methyl cinnamate, ethyl cinnamate, benzaldehyde and so on.
  
  The company has passed ISO9001 quality management system certification, and relying on the concept of independent development and joint development of universities, it has in-depth cooperation with major universities and scientific research institutions in Wuhan.
  
  It has successively obtained excellent companies with integrity standards, top ten outstanding private enterprises, and corporate credit evaluation AAA.
  
  Grade credit companies, etc.